capparis spinosa l. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice

objective: as the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of cs in diabetic mice.materials and methods: both single and repeated oral administrations of aqueous extract of cs were performed in multi-low dose streptozotocin-induced (mlds) diabetic mice. euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3h glucose) to evaluate the effect of cs aqueous extract on insulin sensitivity.results: our study showed that aqueous extract of cs possess a potent hypoglycaemic activity in mlds diabetic mice. furthermore, the analysis perfusion of 3-3h glucose demonstrated  the parallel decrease of basal endogenous glucose production (egp) with the hypoglycaemic activity. egp was lower in cs-treated group when compared to the control group (p<0.001). the euglycemic hyperinsulinemic clamp technique demonstrated that cs treatment improves insulin sensitivity in peripheral tissues.conclusion: we conclude that the antihyperglycemic effet cs is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in mlds diabetic mice.